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GLIS3 drives epithelial–mesenchymal transition and cancer stem–like traits in stomach adenocarcinoma via TGFBR3–Hedgehog signaling

BackgroundGLIS family zinc finger 3 (GLIS3) is a transcription factor implicated in multiple malignancies, but its role in stomach adenocarcinoma (STAD) and its downstream effector axis remain unclear. We investigated whether GLIS3 coordinates epithelial–mesenchymal transition (EMT) and cancer stem...

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Principais autores: Qi Xiao, Hongyang Deng, Jipin Li, Yijun Zheng, Youcheng Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-05-01
Serier:Frontiers in Oncology
Fag:
GLIS3
Hedgehog
EMT
CSC
STAD
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2026.1826297/full
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