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Development of a novel, high-affinity ssDNA trypsin inhibitor

Inhibitors of serine proteases are not only extremely useful in the basic research but are also applied extensively in clinical settings. Using Systematic Evolution of Ligands by Exponential Enrichment (SELEX) approach we developed a family of novel, single-stranded DNA aptamers capable of specific...

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Autori principali: Stanislaw Malicki, Miroslaw Ksiazek, Pawel Majewski, Aleksandra Pecak, Piotr Mydel, Przemyslaw Grudnik, Grzegorz Dubin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2019-01-01
Serie:Journal of Enzyme Inhibition and Medicinal Chemistry
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Accesso online:http://dx.doi.org/10.1080/14756366.2019.1569648
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