Effectively alleviate rheumatoid arthritis via maintaining redox balance, inducing macrophage repolarization and restoring homeostasis of fibroblast-like synoviocytes by metformin-derived carbon dots

Abstract Overproduction of reactive oxygen species (ROS), elevated synovial inflammation, synovial hyperplasia and fibrosis are the main characteristic of microenvironment in rheumatoid arthritis (RA). Macrophages and fibroblast-like synoviocytes (FLSs) play crucial roles in the progression of RA. H...

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Үндсэн зохиолчид:	Rui Zhang, Xingyu Lin, Rongjie Lin, Zhenbin Chen, Chenfang Miao, Yao Wang, Xiaoqin Deng, Jianlong Lin, Shishui Lin, Shaohuang Weng, Min Chen
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2025-01-01
Цуврал:	Journal of Nanobiotechnology
Нөхцлүүд:	Metformin-derived carbon dots Treating rheumatoid arthritis Redox balance Macrophage repolarization Fibroblast-like synoviocytes IL-6/gp130 signaling pathway
Онлайн хандалт:	https://doi.org/10.1186/s12951-025-03159-7
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!