SPARC-modified mesenchymal stem cells promote recovery of β-cells and insulin secretion by calcium ion homeostasis

Abstract Introduction Type 1 diabetes (T1D) results from the destruction of pancreatic β-cells, leading to insulin deficiency. As insulin therapy does not affect disease progression, advancements in immune regulation therapies have emerged, including the reconstitution of the insulin secretory syste...

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Main Authors:	Jiaqi Gao, Balun Li, Hongkai Tian, Chenchen Li, Nikita Merzlikin, Dongyao Han, Zixi Ling, Zengyu Zhang, Wenlong zhu, Jianqi Dai, Lydmila Gerunova, Changrong Lv, Na Li, Jinlian Hua
Format:	Artigo
Language:	Inglês
Published:	BMC 2025-11-01
Series:	Stem Cell Research & Therapy
Subjects:	Diabetes Mesenchymal stem cells Ca2+ Islet beta cell Glucose-stimulated Insulin Secretion
Online Access:	https://doi.org/10.1186/s13287-025-04727-2
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