Inhibition of kidney proximal tubular glucose reabsorption does not prevent against diabetic nephropathy in type 1 diabetic eNOS knockout mice.

BACKGROUND AND OBJECTIVE: Sodium glucose cotransporter 2 (SGLT2) is the main luminal glucose transporter in the kidney. SGLT2 inhibition results in glycosuria and improved glycaemic control. Drugs inhibiting this transporter have recently been approved for clinical use and have been suggested to hav...

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Principais autores:	Muralikrishna Gangadharan Komala, Simon Gross, Harshini Mudaliar, Chunling Huang, Katherine Pegg, Amanda Mather, Sylvie Shen, Carol A Pollock, Usha Panchapakesan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2014-01-01
coleção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC4219667?pdf=render
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