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Single-cell analysis reveals cellular heterogeneity and limits of marker-based assessment in retinal ganglion cell-enriched organoid cultures

Abstract Human pluripotent stem cell (hPSC)-derived retinal organoids provide an in vitro system for generating retinal ganglion cells (RGCs), yet the cellular composition and developmental fidelity of RGC-enriched cultures remain insufficiently characterised. Here, we tested an RGC-enriched approac...

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Principais autores: Jessica Yuen Wuen Ma, Dulce B. Vargas-Landin, Janya Grainok, Alice Pébay
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-04-01
Serier:Molecular Medicine
Fag:
Retinal ganglion cells
Single-cell RNA sequencing
Differentiation
Retinal organoids
hPSC
Online adgang:https://doi.org/10.1186/s10020-026-01488-3
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