Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes

In a synthetic biology approach using Schneider (S2) cells, we show that SLP-76 is directly phosphorylated at tyrosines Y113 and Y128 by SYK in the presence of ITAM-containing adapters such as CD3ζ, DAP12, or FcεRγ. This phosphorylation was dependent on at least one functional ITAM and a functional...

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Prif Awduron:	Frank Fasbender, Maren Claus, Sabine Wingert, Mina Sandusky, Carsten Watzl
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2017-07-01
Cyfres:	Frontiers in Immunology
Pynciau:	natural killer cells synthetic biology signal transduction SLP-76 SYK Src-family kinases
Mynediad Ar-lein:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00789/full
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