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Circulating Cathepsin D Exacerbates Injury‐Induced Brain Damage by Promoting Neutrophil Infiltration Into the Brain

Background Communication between the vascular endothelium and peripheral leukocytes is an important process controlling inflammatory responses in the brain. Increased plasma levels of CTSD (cathepsin D) have been associated with vascular events, but whether circulating CTSD may affect the functional...

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Principais autores: Yu Liang, Dan Zhao, Peng‐Fei Wu, Yong‐Qi Liang, Xue‐Wei Zhang, Jia Xing, Xue Sun, Ming‐Xin An, Jun‐Xiu Shi, Qing‐Hua Gao, Li Tian, Hong‐Zan Sun, Bin Xue, Li‐Bo Jiang, Yu‐Hua Chen, Wei‐Dong Zhao
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-11-01
Serier:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Fag:
brain endothelial cells
brain injury
cathepsin D
neutrophil infiltration
VCAM‐1
Online adgang:https://www.ahajournals.org/doi/10.1161/JAHA.125.043416
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