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Regression of renal cell carcinoma by T cell receptor-engineered T cells targeting a human endogenous retrovirus

Background We discovered a novel human endogenous retrovirus (CT-RCC HERV-E) that was selectively expressed in most clear cell renal cell carcinomas (ccRCC) and served as a source of antigens for T cell-mediated killing. Here, we described the cloning of a novel T cell receptor (TCR) targeting a CT-...

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Ngā kaituhi matua: Long Chen, David F Stroncek, Gang Zeng, Steven Highfill, Robert Reger, Stefan Barisic, Elena Cherkasova, Elizabeth M Brahmbhatt, Timothy T Spear, Ujjawal Savani, Stephanie Pierre, Gina M Scurti, Muna Igboko, Rosa Nadal, Gordon Parry, Annika V Dalheim, Michael I Nishimura, Richard W Childs
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMJ Publishing Group 2024-09-01
Rangatū:Journal for ImmunoTherapy of Cancer
Urunga tuihono:https://jitc.bmj.com/content/12/9/e009147.full
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