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PHGDH drives 5-FU chemoresistance in colorectal cancer through the Hedgehog signaling

Abstract Background Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the de novo Serine synthesis pathway (SSP), a highly regulated pathway overexpressed in several tumors. Specifically, PHGDH expression is dynamically regulated during different stages of tumor progression, prom...

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Furkejuvvon:
Váldodahkkit: Caterina Mancini, Giulia Lori, Gianluca Mattei, Marta Iozzo, Dayana Desideri, Fabio Cianchi, Laura Fortuna, Federico Passagnoli, Daniela Massi, Filippo Ugolini, Luca Messerini, Salvatore Piscuoglio, Antonio Pezone, Francesca Magherini, Alessio Biagioni, Tiziano Lottini, Demetra Zambardino, Giuseppina Ivana Truglio, Elena Petricci, Alberto Magi, Annarosa Arcangeli, Luisa Maresca, Barbara Stecca, Erica Pranzini, Maria Letizia Taddei
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: BMC 2025-07-01
Ráidu:Journal of Experimental & Clinical Cancer Research
Fáttát:
Phosphoglycerate dehydrogenase
Chemo-resistance
5-Fluorouracil
Colorectal cancer
Serine
Stemness
Liŋkkat:https://doi.org/10.1186/s13046-025-03447-y
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