High-Throughput Amplicon-Based Copy Number Detection of 11 Genes in Formalin-Fixed Paraffin-Embedded Ovarian Tumour Samples by MLPA-Seq.

Whilst next generation sequencing can report point mutations in fixed tissue tumour samples reliably, the accurate determination of copy number is more challenging. The conventional Multiplex Ligation-dependent Probe Amplification (MLPA) assay is an effective tool for measurement of gene dosage, but...

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Главные авторы:	Olga Kondrashova, Clare J Love, Sebastian Lunke, Arthur L Hsu, Australian Ovarian Cancer Study (AOCS) Group, Paul M Waring, Graham R Taylor
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2015-01-01
Серии:	PLoS ONE
Online-ссылка:	https://doi.org/10.1371/journal.pone.0143006
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