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Hypertonic sodium lactate improves microcirculation, cardiac function, and inflammation in a rat model of sepsis

Abstract Background Hypertonic sodium lactate (HSL) may be of interest during inflammation. We aimed to evaluate its effects during experimental sepsis in rats (cecal ligation and puncture (CLP)). Methods Three groups were analyzed (n = 10/group): sham, CLP-NaCl 0.9%, and CLP-HSL (2.5 mL/kg/h of flu...

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Autori principali: Emmanuel Besnier, David Coquerel, Geoffrey Kouadri, Thomas Clavier, Raphael Favory, Thibault Duburcq, Olivier Lesur, Soumeya Bekri, Vincent Richard, Paul Mulder, Fabienne Tamion
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2020-06-01
Serie:Critical Care
Soggetti:
Sodium lactate
Sepsis
Metabolism
Microcirculation
Heart failure
Accesso online:http://link.springer.com/article/10.1186/s13054-020-03083-2
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