Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients

Abstract Background The colorectal cancer antigen GUCY2C exhibits unique split tolerance, evoking antigen-specific CD8+, but not CD4+, T-cell responses that deliver anti-tumor immunity without autoimmunity in mice. Here, the cancer vaccine Ad5-GUCY2C-PADRE was evaluated in a first-in-man phase I cli...

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Detalhes bibliográficos

Principais autores:	Adam E. Snook, Trevor R. Baybutt, Bo Xiang, Tara S. Abraham, John C. Flickinger, Terry Hyslop, Tingting Zhan, Walter K. Kraft, Takami Sato, Scott A. Waldman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMJ Publishing Group 2019-04-01
coleção:	Journal for ImmunoTherapy of Cancer
Assuntos:	Colorectal cancer GUCY2C Guanylyl cyclase C Vaccine
Acesso em linha:	http://link.springer.com/article/10.1186/s40425-019-0576-2
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