Discovery and validation of frameshift-derived neopeptides in Lynch syndrome: paving the way for novel cancer prevention strategies

Background Lynch syndrome (LS), caused by germline pathogenic variants in the mismatch repair genes, leads to high rates of frameshift-derived neopeptide (FSDN) expression due to microsatellite instability (MSI). While colorectal cancer (CRC) prevention is effective, most LS-related tumors lack such...

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المؤلفون الرئيسيون:	Marta Pineda, Sabela Carballal, María Pellisé, Liseth Rivero, Francesc Balaguer, Fátima Marín, Leticia Moreira, Teresa Ocaña, Manel Juan, Daniel Benitez-Ribas, Georgina Flórez-Grau, Joaquín Castillo-Iturra, Cristina Bayó, Giancarlo Castellano, Hardeep Kumari, Maria Daca-Alvarez, Oswaldo Ortiz, Rebeca Moreira, Julia Canet-Hermida, Capella Gabriel
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	BMJ Publishing Group 2025-04-01
سلاسل:	Journal for ImmunoTherapy of Cancer
الوصول للمادة أونلاين:	https://jitc.bmj.com/content/13/4/e011177.full
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!