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VS-4718 enhances apoptosis induced by low-dose carfilzomib and overcomes carfilzomib resistance in PSMB5-mutated proteasome inhibitor resistant multiple myeloma

Abstract The introduction of proteasome inhibitors (PIs) into multiple myeloma (MM) treatment has substantially improved therapeutic options and survival rates. However, the development of resistance to PIs as well as serious side effects of PI treatment continue to justify the search for effective,...

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Principais autores: Ellen Leich-Zbat, Sofia Catalina Heredia-Guerrero, Marietheres Evers, Thorsten Stühmer, Tina Grieb, Hilka Rauert-Wunderlich, Ralf C. Bargou, Andreas Rosenwald, Manik Chatterjee, Daniela Brünnert
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2026-03-01
Serier:Scientific Reports
Fag:
Multiple myeloma
Proteasome inhibitors
PYK2
VS-4718
Carfilzomib
Proteasome inhibitor resistance
Online adgang:https://doi.org/10.1038/s41598-026-43205-4
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