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ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli

ABSTRACT Colibactin is a nonribosomal peptide/polyketide hybrid natural product expressed by different members of the Enterobacteriaceae which can be correlated with induction of DNA double-strand breaks and interference with cell cycle progression in eukaryotes. Regulatory features of colibactin ex...

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Principais autores: Alexander Wallenstein, Nadine Rehm, Marina Brinkmann, Martina Selle, Nadège Bossuet-Greif, Daniel Sauer, Boyke Bunk, Cathrin Spröer, Haleluya Tesfaye Wami, Stefan Homburg, Rudolf von Bünau, Simone König, Jean-Philippe Nougayrède, Jörg Overmann, Eric Oswald, Rolf Müller, Ulrich Dobrindt
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020-08-01
coleção:mSphere
Assuntos:
secondary metabolite
polyketide
cytopathic effect
RNA-seq
VNTR
Acesso em linha:https://journals.asm.org/doi/10.1128/msphere.00591-20
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