Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels

Summary: Ion channel modulation by general anesthetics is a vital pharmacological process with implications for receptor biophysics and drug development. Functional studies have implicated conserved sites of both potentiation and inhibition in pentameric ligand-gated ion channels, but a detailed str...

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Bibliografiske detaljer

Principais autores:	Zaineb Fourati, Rebecca J. Howard, Stephanie A. Heusser, Haidai Hu, Reinis R. Ruza, Ludovic Sauguet, Erik Lindahl, Marc Delarue
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2018-04-01
Serier:	Cell Reports
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2211124718304844
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