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Priming antibody responses to the fusion peptide in rhesus macaques

Abstract Immunodominance of antibodies targeting non-neutralizing epitopes and the high level of somatic hypermutation within germinal centers (GCs) required for most HIV broadly neutralizing antibodies (bnAbs) are major impediments to the development of an effective HIV vaccine. Rational protein va...

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Autores principales: Christopher A. Cottrell, Payal P. Pratap, Kimberly M. Cirelli, Diane G. Carnathan, Chiamaka A. Enemuo, Aleksandar Antanasijevic, Gabriel Ozorowski, Leigh M. Sewall, Hongmei Gao, Joel D. Allen, Bartek Nogal, Murillo Silva, Jinal Bhiman, Matthias Pauthner, Darrell J. Irvine, David Montefiori, Max Crispin, Dennis R. Burton, Guido Silvestri, Shane Crotty, Andrew B. Ward
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Portfolio 2024-07-01
Colección:npj Vaccines
Acceso en línea:https://doi.org/10.1038/s41541-024-00918-9
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