Targeting CLDN18.2 in cancers of the gastrointestinal tract: New drugs and new indications

Cancers of the gastrointestinal (GI) tract greatly contribute to the global cancer burden and cancer-related death. Claudin-18.2(CLDN18.2), a transmembrane protein, is a major component of tight junctions and plays an important role in the maintenance of barrier function. Its characteristic widespre...

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Autors principals:	Jinxia Chen, Zhiyuan Xu, Can Hu, Shengjie Zhang, Mengli Zi, Li Yuan, Xiangdong Cheng
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-03-01
Col·lecció:	Frontiers in Oncology
Matèries:	Claudin-18.2 gastrointestinal (GI) tract monoclonal antibody antibody–drug conjugate (ADC) chimeric antigen receptor T (CAR-T)
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1132319/full
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