Replication in human cells supersedes serum antigenic match for the in vivo efficacy of an A/H1N1pdm09 LAIV virus

Abstract For FluMist®/Fluenz live attenuated influenza vaccine (LAIV), efficient virus replication in human nasal epithelial cells (hNEC) is an important factor in vaccine effectiveness (VE). The necessity of antigenic similarity of LAIV viruses to the WHO-recommended strains for VE is less clear. H...

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Autors principals:	Steffan Llewellyn, Katarzyna E. Schewe, Sameer Ayaz, David Burbidge, Shaun Cooper, Jonathan Crowe, Sarah Dodd, Jemma Shapanis, Katie Tudor, Kathryn Ryan, Lauren Parker, Oliver Dibben
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-11-01
Col·lecció:	npj Vaccines
Accés en línia:	https://doi.org/10.1038/s41541-025-01281-z
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