Salvinorin A exerts antiepileptic effects by regulating PINK1/Parkin-mediated mitophagy in the hippocampus of pilocarpine-induced chronic epileptic mice

Objective To investigate the antiepileptic effects of the natural κ-opioid receptor (KOR) agonist Salvinorin A (SA) on pilocarpine-induced chronic epileptic mice and to explore the underlying mechanisms.Methods A total of 45 male 8-week-old C57BL/6J mice were randomly divided into four groups: a nor...

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Autori principali:	CAI Jiheng, WEI Ruyuan, LI Kexue, WANG Jue, JI Miaojin
Natura:	Artigo
Lingua:	Chinês
Pubblicazione:	Editorial Office of Journal of Xuzhou Medical University 2026-03-01
Serie:	徐州医科大学学报
Soggetti:	epilepsy mitophagy κ-opioid receptor salvinorin a pink1/parkin/lc3 pathway hippocampus
Accesso online:	https://xb.xzhmu.edu.cn/article/doi/10.12467/j.issn.2096-3882.20250912
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