The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling

Summary: Defects in primary cilia, cellular antennas that control multiple intracellular signaling pathways, underlie several neurodevelopmental disorders, but it remains unknown how cilia control essential steps in human brain formation. Here, we show that cilia are present on the apical surface of...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Leah Schembs, Ariane Willems, Kerstin Hasenpusch-Theil, James D. Cooper, Katie Whiting, Karen Burr, Sunniva M.K. Bøstrand, Bhuvaneish T. Selvaraj, Siddharthan Chandran, Thomas Theil
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-05-01
coleção:	Cell Reports
Assuntos:	CP: Neuroscience
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124722005824
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!