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Using family-based imputation in genome-wide association studies with large complex pedigrees: the Framingham Heart Study.

Imputation has been widely used in genome-wide association studies (GWAS) to infer genotypes of un-genotyped variants based on the linkage disequilibrium in external reference panels such as the HapMap and 1000 Genomes. However, imputation has only rarely been performed based on family relationships...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Ming-Huei Chen, Jie Huang, Wei-Min Chen, Martin G Larson, Caroline S Fox, Ramachandran S Vasan, Sudha Seshadri, Christopher J O'Donnell, Qiong Yang
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Public Library of Science (PLoS) 2012-01-01
Rangatū:PLoS ONE
Urunga tuihono:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0051589&type=printable
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