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CpG Methylation Profiles of HIV-1 Proviral DNA in Individuals on ART

The latent HIV-1 reservoir is comprised of stably integrated and intact proviruses with limited to no viral transcription. It has been proposed that latent infection may be maintained by methylation of pro-viral DNA. Here, for the first time, we investigate the cytosine methylation of a replication...

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Principais autores: Valerie F. Boltz, Cristina Ceriani, Jason W. Rausch, Wei Shao, Michael J. Bale, Brandon F. Keele, Rebecca Hoh, Jeffrey M. Milush, Steve G. Deeks, Frank Maldarelli, Mary F. Kearney, John M. Coffin
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2021-04-01
coleção:Viruses
Assuntos:
CpG dinucleotide methylation
HIV latency
single genome sequencing
RNA expression
transcriptional silencing
Acesso em linha:https://www.mdpi.com/1999-4915/13/5/799
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