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Anticancer and Structure Activity Relationship of Non-Symmetrical Choline Kinase Inhibitors

Choline kinase inhibitors are an outstanding class of cytotoxic compounds useful for the treatment of different forms of cancer since aberrant choline metabolism is a feature of neoplastic cells. Here, we present the most in-depth structure-activity relationship studies of an interesting series of n...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Santiago Schiaffino-Ortega, Elena Mariotto, Pilar María Luque-Navarro, María Kimatrai-Salvador, Pablo Rios-Marco, Ramon Hurtado-Guerrero, Carmen Marco, María Paz Carrasco-Jimenez, Giampietro Viola, Luisa Carlota López-Cara
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2021-08-01
Schriftenreihe:Pharmaceutics
Schlagworte:
antitumoral drug
choline kinase inhibition
choline uptake
Online-Zugang:https://www.mdpi.com/1999-4923/13/9/1360
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