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Mutations associated with Alzheimer’s disease and aged serum synergistically elicit blood-brain barrier dysfunction in a tissue-engineered model

Abstract Background Alzheimer’s disease is heterogeneous with a wide range of etiological subtypes derived from multiple risk factors. Many of these risk factors are either directly or indirectly related to stresses that act on the blood-bran barrier. Deconvoluting the influence of these stresses on...

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Bibliografische Detailangaben
Hauptverfasser: Tracy D. Chung, Lily Liang, Linus Wang, Elizabeth G. Kim, Sukriti Gupta, Ikshu Pandey, Peter C. Searson
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2026-02-01
Schriftenreihe:Fluids and Barriers of the CNS
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Online-Zugang:https://doi.org/10.1186/s12987-026-00773-x
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