Deep Learning-Guided Engineering of <i>Bst</i> DNA Polymerase Improves LAMP-Based Detection of Foodborne Pathogens

Loop-mediated isothermal amplification (LAMP) is a widely used nucleic acid detection method, but its application is often limited by the suboptimal performance of wild-type <i>Bacillus stearothermophilus</i> (<i>Bst</i>) DNA polymerase. This study employed a combined deep learning and semi-rational...

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Principais autores:	Haoting Chen, Jingfeng Zhang, Xiaoli Xu, Huang Zhang, Yanlei Chang, Lei Shi, Lichao Zhao
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2026-04-01
Series:	Microorganisms
Assuntos:	<i>Bst</i> DNA polymerase foodborne pathogen detection deep learning LAMP fusion protein engineering
Acceso en liña:	https://www.mdpi.com/2076-2607/14/5/954
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