Pharmacological effects of a new soluble guanylate cyclase stimulator in experimental pulmonary arterial hypertension

Aim. To assess the effect of an indolinone derivative (2-[2-[(5RS)-5-(hydroxymethyl)-3-methyl-1,3-oxazolidine-2yliden]-2-cyanoethylidene]-1H-indole-3(2H)-one (codename – GRS) on right ventricular contractility, endothelial vasodilator function, and histologic changes in the lungs and heart in a rat...

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Bibliografische gegevens

Hoofdauteurs:	V. V. Bykov, A. V. Bykova, S. A. Stankevich, O. I. Aliev, A. V. Sidekhmenova, O. I. Dunaeva, V. A. Khazanov, A. I. Vengerovskii, V. V. Udut
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Siberian State Medical University (Tomsk) 2023-04-01
Reeks:	Бюллетень сибирской медицины
Onderwerpen:	pulmonary arterial hypertension model soluble guanylate cyclase stimulators indolinone derivative grs riociguat
Online toegang:	https://bulletin.ssmu.ru/jour/article/view/5127
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