Validation of a functional human AD model with four AD therapeutics utilizing patterned ipsc-derived cortical neurons integrated with microelectrode arrays

Abstract Preclinical methods are needed for screening potential Alzheimer’s disease (AD) therapeutics that recapitulate phenotypes found in the Mild Cognitive Impairment (MCI) stage or even before this stage of the disease. This would require a phenotypic system that reproduces cognitive deficits wi...

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Detalhes bibliográficos

Principais autores:	Julbert Caneus, Kaveena Autar, Nesar Akanda, Marcella Grillo, Christopher J. Long, Max Jackson, Sarah Lindquist, Xiufang Guo, Dave Morgan, James J. Hickman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-10-01
coleção:	Scientific Reports
Assuntos:	Alzheimer’s disease Long-term potentiation Human-on-a-Chip Amyloid-beta42 Drug efficacy Microelectrode arrays
Acesso em linha:	https://doi.org/10.1038/s41598-024-73869-9
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