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MARCH6 suppresses Tembusu virus replication by targeting viral NS5 protein for TOLLIP-mediated selective autophagic degradation

ABSTRACT The E3 ligase membrane-associated RING finger 6 (MARCH6) plays a pivotal role in various cellular processes; however, its role in viral defense remains largely unexplored. In this study, we have elucidated a novel antiviral mechanism of avian MARCH6 against duck Tembusu virus (TMUV), reveal...

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Principais autores: Peng Zhou, Wanrong Wu, Jiani Wei, Yueshan Yang, Anan Jongkaewwattana, Yuncai Xiao, Hui Jin, Hongbo Zhou, Rui Luo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2025-07-01
Serier:Journal of Virology
Fag:
MARCH6
TMUV replication
NS5
TOLLIP
autophagic degradation
Online adgang:https://journals.asm.org/doi/10.1128/jvi.00735-25
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