Design, Synthesis, and In Vitro, In Silico and In Cellulo Evaluation of New Pyrimidine and Pyridine Amide and Carbamate Derivatives as Multi-Functional Cholinesterase Inhibitors

Alzheimer disease is an age-linked neurodegenerative disorder representing one of the greatest medical care challenges of our century. Several drugs are useful in ameliorating the symptoms, even if none could stop or reverse disease progression. The standard approach is represented by the cholineste...

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Автори:	Martina Bortolami, Fabiana Pandolfi, Valeria Tudino, Antonella Messore, Valentina Noemi Madia, Daniela De Vita, Roberto Di Santo, Roberta Costi, Isabella Romeo, Stefano Alcaro, Marisa Colone, Annarita Stringaro, Alba Espargaró, Raimon Sabatè, Luigi Scipione
Формат:	Artigo
Мова:	Inglês
Опубліковано:	MDPI AG 2022-05-01
Серія:	Pharmaceuticals
Предмети:	acetylcholinesterase inhibitors butyrylcholinesterase inhibitors multifunctional compounds amyloid aggregation tau aggregation metal chelation
Онлайн доступ:	https://www.mdpi.com/1424-8247/15/6/673
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