Cediranib with weekly paclitaxel or olaparib versus weekly paclitaxel for advanced or recurrent endometrial cancer (COPELIA): a multicentre, open-label, randomised, phase 2 trial in the UKResearch in context

Summary: Background: Patients with advanced or recurrent endometrial cancer have poor survival outcomes because effective treatment options remain limited. We investigated the efficacy and safety of cediranib plus weekly paclitaxel or olaparib versus weekly paclitaxel alone after prior platinum-bas...

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Detalhes bibliográficos

Principais autores:	Robert D. Morgan, Catharine Porter, Cong Zhou, Rebecca Kristeleit, Sudha Desai, Ignacio Vazquez, Angela George, Gemma Eminowicz, Axel Walther, Adrian Franklin, Azmat H. Sadozye, Andrew Hughes, Louise Hanna, Rene Roux, Rosemary Lord, Rebecca Bowen, Joey Wood, Clara Sentamans, Ann White, Angela C. Casbard, Alys Humphrys, Jennifer B. Swettenham, Lisette S. Nixon, Richard Adams, Ruby Ray, Elena Brogden, Wendy E. Powell, Joanna Canham, Tracy M. Cox, Monica Narasimham, Helen Lowe, Leah Ensell, Mohammed Zubair, Karen Morris, Molly Glenister-Doyle, Ariadna Fuertes Gassio, Derrick Morgan, Dylan Broughton, Margherita Carucci, Phillip J. Monaghan, Jonathan Tugwood, Richard J. Edmondson, Caroline Dive, Gordon C. Jayson, Andrew R. Clamp
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-06-01
coleção:	EClinicalMedicine
Assuntos:	Clinical trial Endometrial cancer Paclitaxel Cediranib Olaparib Plasma Tie2
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589537026002610
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