Statin therapy with CD19-directed CAR-T therapy improves outcomes in relapsed or refractory large B-cell lymphoma

Abstract: Chimeric antigen receptor T-cell (CAR-T) therapy has improved outcomes for patients with relapsed or refractory large B-cell lymphoma (LBCL). However, up to 60% will eventually relapse. Hypercholesterolemia has been implicated in oncogenesis and T-cell exhaustion, and statin therapy has de...

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Main Authors:	Ethan A. Burns, Noah Giese, Sunil Mathur, Meera Khosla, Shubham Adroja, Hala Hassanain, Jacqueline Rios, Godsfavour Umoru, Shilpan Shah, Hanh Mai, Carrie Yuen, Chih-Hang Anthony Tang, Chih-Chi Andrew Hu, Siddhartha Ganguly, Carlos A. Ramos, Helen E. Heslop, Sai Ravi Pingali
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2026-03-01
Series:	Blood Immunology & Cellular Therapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S3050597625000211
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