Prolonged exposure to lung-derived cytokines is associated with activation of microglia in patients with COVID-19

BACKGROUND Survivors of pneumonia, including SARS-CoV-2 pneumonia, are at increased risk for cognitive dysfunction and dementia. In rodent models, cognitive dysfunction following pneumonia has been linked to the systemic release of lung-derived pro-inflammatory cytokines. Microglia are poised to res...

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Bibliografske podrobnosti

Principais autores:	Rogan A. Grant, Taylor A. Poor, Lango Sichizya, Estefani Diaz, Joseph I. Bailey, Sahil Soni, Karolina J. Senkow, Xóchitl G. Pérez-Leonor, Hiam Abdala-Valencia, Ziyan Lu, Helen K. Donnelly, Lacy M. Simons, Egon A. Ozer, Robert M. Tighe, Jon W. Lomasney, Richard G. Wunderink, Benjamin D. Singer, Alexander V. Misharin, G.R. Scott Budinger, for The Northwestern University Successful Clinical Response In Pneumonia Therapy (NU SCRIPT) Investigators
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Clinical investigation 2024-04-01
Serija:	JCI Insight
Teme:	COVID-19 Immunology
Online dostop:	https://doi.org/10.1172/jci.insight.178859
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