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Targeting autophagy impairment improves the phenotype of a novel CLN8 zebrafish model

CLN8 is an endoplasmic reticulum cargo receptor and a regulator of lysosome biogenesis whose loss of function leads to neuronal ceroid lipofuscinosis. CLN8 has been linked to autophagy and lipid metabolism, but much remains to be learned, and there are no therapies acting on the molecular signatures...

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Principais autores: Maria Marchese, Sara Bernardi, Asahi Ogi, Rosario Licitra, Giada Silvi, Serena Mero, Daniele Galatolo, Nicola Gammaldi, Stefano Doccini, Gian Michele Ratto, Simona Rapposelli, Stephan C.F. Neuhauss, Jingjing Zang, Silvia Rocchiccioli, Elena Michelucci, Elisa Ceccherini, Filippo M. Santorelli
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-07-01
Serier:Neurobiology of Disease
Fag:
Neuronal ceroid lipofuscinosis 8
Zebrafish
Autophagy
Drug screening
Online adgang:http://www.sciencedirect.com/science/article/pii/S0969996124001359
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