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Regional Conservation and Transcriptional Regulation of Tumor-Associated Genes by macroH2A1 Deposition in Mammalian Cells

Histone variant macroH2A1 (mH2A1) has been widely recognized as a suppressor of gene expression. Recently, a cell cycle-dependent deposition of mH2A1 was discovered in mouse cells, but whether this process exists in human chromatin is unclear, which might be crucial for related diseases, particularl...

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Principais autores: Yongzhuo Deng, Zeqian Xu, Le Zhang, Bishan Ye, Zhifeng Shao, Xinhui Li
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-09-01
Serier:Biomolecules
Fag:
macroH2A1
mitosis
nChIP seq
transcriptional regulation
tumorigenesis
Online adgang:https://www.mdpi.com/2218-273X/15/10/1386
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