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Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia/reperfusion injury mice inhibiting neuron ferroptosis

Abstract Ferroptosis plays a critical role in ischemic stroke, and anti-ferroptosis strategies were regarded as potentially effective measures. Based on ferroptosis-related mechanisms, this study aims to design and prepare anti-ferroptosis exosomes from adipose-derived mesenchymal stem cells (ADSC-E...

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Principais autores: Yong Wang, Huicong Niu, Luyu Li, Jing Han, Zhuohang Liu, Min Chu, Xianyi Sha, Jing Zhao
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2023-03-01
Series:Journal of Nanobiotechnology
Assuntos:
Cerebral ischemia
Exosomes
Ferroptosis
Intranasal administration
CHAC1
Acceso en liña:https://doi.org/10.1186/s12951-023-01862-x
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