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In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents

BACKGROUND Only benznidazole (Bnz) (1) and nifurtimox (Nfx) (2) are licensed for the treatment of Chagas disease although their safety and efficacy profile are far from ideal. Farmanguinhos from Fiocruz has developed seven nitroimidazole compounds (4-10) analogs of megazol (3). OBJECTIVES To eval...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Ana Claudia Manoel Von Trompowsky, Taline Ramos Conde, Renata Calil Lemos, Bruna Maria CS Quaresma, Marcelly Cristina SR Pitombeira, Alcione Silva de Carvalho, Núbia Boechat, Kelly Salomão, Solange Lisboa de Castro, Helena Pereira da Silva Zamith
Format: Artigo
Sprache:Inglês
Veröffentlicht: Fundação Oswaldo Cruz (FIOCRUZ)
Schriftenreihe:Memorias do Instituto Oswaldo Cruz
Schlagworte:
genotoxicity
mutagenicity
megazol
nitroimidazoles
Online-Zugang:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762019000100335&lng=en&tlng=en
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