Rhein Relieves Oxidative Stress in an Aβ1-42 Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis

Neuronal mitochondrial oxidative stress induced by β-amyloid (Aβ) is an early event of Alzheimer’s disease (AD). Emerging evidence has shown that antioxidant therapy represents a promising therapeutic strategy for the treatment of AD. In this study, we investigated the antioxidant activity of rhein...

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Autori principali:	Zhihui Yin, Xinyue Geng, Zhengyi Zhang, Ying Wang, Xiaoyan Gao
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2021-09-01
Serie:	Frontiers in Pharmacology
Soggetti:	β-amyloid oxidative stress rhein mitochondrial biogenesis sirtuin 1 peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Accesso online:	https://www.frontiersin.org/articles/10.3389/fphar.2021.746711/full
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