Acquired modification of sphingosine-1-phosphate lyase activity is not related to adrenal insufficiency

Abstract Background Congenital sphingosine-1-phosphate (S1P) lyase deficiency due to biallelic mutations in SGPL1 gene has recently been described in association with primary adrenal insufficiency and steroid-resistant nephrotic syndrome. S1P lyase, on the other hand, is therapeutically inhibited by...

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Autores principales:	Gulin Sunter, Ece Oge Enver, Azad Akbarzade, Serap Turan, Pinar Vatansever, Dilek Ince Gunal, Goncagul Haklar, Abdullah Bereket, Kadriye Agan, Tulay Guran
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2018-04-01
Colección:	BMC Neurology
Materias:	Sphingosine-1-phosphate lyase Fingolimod Adrenal Multiple sclerosis
Acceso en línea:	http://link.springer.com/article/10.1186/s12883-018-1049-9
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