Carvedilol targets β-arrestins to rewire innate immunity and improve oncolytic adenoviral therapy
Hoare et al describe a drug-repurposing approach and report that carvedilol, a β-arrestin-biased β-blocker, exhibits synergistic anti-ovarian cancer effects with oncolytic adenovirus. The study reveals that carvedilol augments the activity of oncolytic adenoviruses via β-arrestins to re-wire cytokin...
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| Principais autores: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Portfolio
2022-02-01
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| 叢編: | Communications Biology |
| 在線閱讀: | https://doi.org/10.1038/s42003-022-03041-4 |
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