CD4 and CD8 T Cell Memory Interactions Alter Innate Immunity and Organ Injury in the CLP Sepsis Model

The role of T cell memory in sepsis is poorly understood. Recent work has demonstrated that mice exposed to frequent antigenic stimulation, in contrast to laboratory mice, better recapitulate the human T cell repertoire. This difference may profoundly alter responses to inflammatory insults. We indu...

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Principais autores:	Matthew D. Taylor, Tiago D. Fernandes, Alexander P. Kelly, Mabel N. Abraham, Clifford S. Deutschman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-11-01
coleção:	Frontiers in Immunology
Assuntos:	cecal ligation and puncture sepsis innate immunity organ dysfunction T cell memory CD4 T Cells
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2020.563402/full
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