Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons

Amyotrophic Lateral Sclerosis (ALS) is an incurable neurodegenerative disease characterized by dysfunction and loss of upper and lower motor neurons (MN). Despite several studies identifying drastic alterations affecting synaptic composition and functionality in different experimental models, the sp...

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Detalhes bibliográficos

Principais autores:	Daniel Sommer, Sandeep Rajkumar, Mira Seidel, Amr Aly, Albert Ludolph, Ritchie Ho, Tobias M. Boeckers, Alberto Catanese
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-06-01
coleção:	Frontiers in Molecular Neuroscience
Assuntos:	hiPSC ALS (amyotrophic lateral sclerosis) motor neuron (MN) synapse transcriptomic (RNA-Seq) neuronal excitability
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnmol.2022.894230/full
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