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Common genetic variations in telomere length genes and lung cancer: a Mendelian randomisation study and its novel application in lung tumour transcriptome

Background: Genome-wide association studies (GWASs) have identified genetic susceptibility variants for both leukocyte telomere length (LTL) and lung cancer susceptibility. Our study aims to explore the shared genetic basis between these traits and investigate their impact on somatic environment of...

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Principais autores: Ricardo Cortez Cardoso Penha, Karl Smith-Byrne, Joshua R Atkins, Philip C Haycock, Siddhartha Kar, Veryan Codd, Nilesh J Samani, Christopher Nelson, Maja Milojevic, Aurélie AG Gabriel, Christopher Amos, Paul Brennan, Rayjean J Hung, Linda Kachuri, James D Mckay
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2023-04-01
Serier:eLife
Fag:
telomere length
lung cancer
GWAS
Mendelian randomisation
gene expression
Genome Stability
Online adgang:https://elifesciences.org/articles/83118
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