Structure-activity relationship and target investigation of 2-aryl quinolines with nematocidal activity

Within the context of our anthelmintic discovery program, we recently identified and evaluated a quinoline derivative, called ABX464 or obefazimod, as a nematocidal candidate; synthesised a series of analogues which were assessed for activity against the free-living nematode Caenorhabditis elegans;...

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Autors principals:	Harrison T. Shanley, Aya C. Taki, Nghi Nguyen, Tao Wang, Joseph J. Byrne, Ching-Seng Ang, Michael G. Leeming, Shuai Nie, Nicholas Williamson, Yuanting Zheng, Neil D. Young, Pasi K. Korhonen, Andreas Hofmann, Bill C.H. Chang, Tim N.C. Wells, Cécile Häberli, Jennifer Keiser, Abdul Jabbar, Brad E. Sleebs, Robin B. Gasser
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-04-01
Col·lecció:	International Journal for Parasitology: Drugs and Drug Resistance
Matèries:	Anthelmintics Drug discovery Haemonchus contortus Target identification Thermal proteome profiling In silico docking
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211320724000034
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