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Analgesic and Anti-Inflammatory Effects of the Synthetic Neurosteroid Analogue BNN27 during CFA-Induced Hyperalgesia

Dehydroepiandrosterone (DHEA), an adrenal and neurosteroid hormone with strong neuroprotective and immunomodulatory properties, and ligand for all high-affinity neurotrophin tyrosine kinase receptors (Trk), also exerts important effects on hyperalgesia. Its synthetic, 17-spiro-epoxy analogue, BNN27,...

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Principais autores: Smaragda Poulaki, Olga Rassouli, George Liapakis, Achille Gravanis, Maria Venihaki
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-09-01
Serier:Biomedicines
Fag:
hyperalgesia
inflammation
neurosteroids
cytokines
NGF
opioids
Online adgang:https://www.mdpi.com/2227-9059/9/9/1185
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