Fluoxetine induces alkalinization of astroglial cytosol through stimulation of sodium-hydrogen exchanger 1: Dissection of intracellular signalling pathways

Clinical evidence suggest astrocytic abnormality in major depression while treatment with anti-psychotic drugs affects astroglial functions. Astroglial cells are involved in pH homeostasis of the brain by transporting protons (through sodium-proton transporter 1, NHE1, glutamate transporters EAAT1/2...

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Detalhes bibliográficos

Principais autores:	Jienan eRen, Dan eSong, Qiufang eBai, Alexej eVerkhratsky, Liang ePeng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2015-03-01
coleção:	Frontiers in Cellular Neuroscience
Assuntos:	Astrocytes Fluoxetine Akt NHE1 ERK1/2 pHi
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00061/full
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