4,4′-methylenebis(2-chloroaniline) induces chromosome aneuploidy associated with premature chromatid separation in mammalian cells: A possible carcinogenic mechanism

In Japan, several workers were diagnosed with bladder cancer 10–40 years after exposure to 4,4′-methylenebis(2-chloroaniline) (MOCA), mainly through the skin. MOCA also induces bladder cancer in dogs and nonbladder (breast, liver, lung) cancers in rodents. MOCA with S9 fractions contains mutagenic m...

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Principais autores:	Saho Kobayashi, Hiroki Kashiwagi, Kenichi Kobayashi, Masaoki Kohzaki
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2025-03-01
Series:	Ecotoxicology and Environmental Safety
Assuntos:	MOCA (MBOCA) Aromatic amines Bladder cancer Chromosomal aneuploidy Cohesion defects Mitosis
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S0147651325003173
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