Structural basis for lysophosphatidylserine recognition by GPR34

Abstract GPR34 is a recently identified G-protein coupled receptor, which has an immunomodulatory role and recognizes lysophosphatidylserine (LysoPS) as a putative ligand. Here, we report cryo-electron microscopy structures of human GPR34-Gi complex bound with one of two ligands bound: either the Ly...

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主要な著者:	Tamaki Izume, Ryo Kawahara, Akiharu Uwamizu, Luying Chen, Shun Yaginuma, Jumpei Omi, Hiroki Kawana, Fengjue Hou, Fumiya K. Sano, Tatsuki Tanaka, Kazuhiro Kobayashi, Hiroyuki H. Okamoto, Yoshiaki Kise, Tomohiko Ohwada, Junken Aoki, Wataru Shihoya, Osamu Nureki
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2024-02-01
シリーズ:	Nature Communications
オンライン･アクセス:	https://doi.org/10.1038/s41467-024-45046-z
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