FLI1 promotes IFN-γ-induced kynurenine production to impair anti-tumor immunity

Abstract Nasopharyngeal carcinoma (NPC)-mediated immunosuppression within the tumor microenvironment (TME) frequently culminates in the failure of otherwise promising immunotherapies. In this study, we identify tumor-intrinsic FLI1 as a critical mediator in impairing T cell anti-tumor immunity. A me...

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Главные авторы:	Enni Chen, Jiawei Wu, Jiajia Huang, Wancui Zhu, Haohui Sun, Xiaonan Wang, Dagui Lin, Xiaodi Li, Dingbo Shi, Zhiqiao Liu, Jinsheng Huang, Miao Chen, Fangyun Xie, Wuguo Deng
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2024-05-01
Серии:	Nature Communications
Online-ссылка:	https://doi.org/10.1038/s41467-024-48397-9
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